Scientists Uncover Aging Mechanisms Through Spatial Transcriptomics

New Delhi, November 10, 2024 - A breakthrough in understanding the aging process has been achieved by a team of scientists from the Chinese Academy of Sciences (CAS) and BGI Research. Their study, published in the prestigious journal Cell, explores the role of immunoglobulins in aging by creating detailed spatial transcriptomic maps of various organs in male mice.

The researchers analyzed millions of spatial spots across nine organs to produce these high-precision maps, which illustrate the spatial distribution of over 70 cell types. This innovative approach, termed Gerontological Geography (GG), has revealed critical insights into how aging manifests spatially within the body.

Professor Liu Guanghui, a corresponding author of the study, explained, "This landscape is a significant step forward, pinpointing the epicenters of ageing within multiple organs and uncovering the accumulation of immunoglobulins as a key aging characteristic and driver."

The findings highlight two universal signs of systemic aging: increased spatial structural disorder and the loss of cellular identity. These factors suggest that damage to the spatial structure of tissues might be a primary cause of organ function decline with age.

The study also introduced the concept of senescence-sensitive spots (SSS), areas within tissues that are more vulnerable to the effects of aging. These spots showed higher levels of structural entropy and greater loss of cellular identity, indicating they could be the focal points for aging-related changes within organs.

"This is the first study to map the spatial transcriptome of pan-organ ageing in mammals, revealing key aging hallmarks and locating the core regions and microenvironmental characteristics of ageing sensitivity," added Professor Guanghui.

This pioneering research not only expands our understanding of the aging process but also sets the stage for new strategies to delay aging and prevent related diseases, offering hope for healthier, longer lives.

(Source: Alayaran.com)