Breakthrough: Rare Genetic Mutation May Allow Some to Thrive on Minimal Sleep

A groundbreaking study has revealed a possible genetic mutation that may enable some individuals to function well despite getting as little as four to six hours of sleep per night. The mutation, named SIK3-N783Y, was identified in a human "super-sleeper" and found to impact the sleep-wake cycle, leading to more deep sleep. This rare genetic adaptation has sparked hope for researchers that it could lead to new therapies for sleep disorders.

According to experts, the typical recommended sleep duration for adults is seven to nine hours per night, with prolonged sleep deprivation linked to conditions such as Alzheimer's disease and heart disease. However, a study published in the journal PNAS discovered that not everyone with a shorter sleep cycle had underlying health issues.

The research involved a genetic scientist, Ying-Hui Fu from the University of California, who identified the SIK3-N783Y mutation in the super-sleeper. The team then conducted studies on genetically modified mice to better understand the effects of the mutation. Results showed that mice with the mutation slept 31 minutes less than those without it and experienced a significant decrease in sleep time when subjected to gentle handling, simulating sleep deprivation.

According to Dr. Fu, "Our bodies continue to work when we go to bed. These people [natural short sleepers], all these functions our bodies are doing while we are sleeping, they can just perform at a higher level than we can." The study's findings could lead to the development of new therapies for sleep disorders and improve sleep quality in individuals.

Further research revealed additional pathways that could be involved in regulating sleep duration.